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      <journal-id journal-id-type="publisher-id">odmj</journal-id>
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        <journal-title xml:lang="en">OncoDaily Medical Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">ODMJ</abbrev-journal-title>
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      <issn pub-type="epub">3067-6444</issn>
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        <publisher-name>OncoDaily Medical Journal</publisher-name>
        <publisher-loc>
          <country>US</country>
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    <article-meta>
      <article-id pub-id-type="publisher-id">4309</article-id>
      <article-id pub-id-type="doi">10.69690/ODMJ-002-0701-4309</article-id>
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        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Reviews</subject>
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      <title-group>
        <article-title xml:lang="en">Current Perspective of Gastro-intestinal Cancer in Guatemala</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Fallas</surname>
            <given-names>Rixci Augusto Ramírez</given-names>
          </name>
          <aff xml:lang="en">Head of the Oncology Department at the General Hospital for Diseases of the Guatemalan Social Security Institute of Guatemala (IGSS)</aff>
          <email>rixci@hotmail.com</email>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>López</surname>
            <given-names>Daniel Estuardo Rosales</given-names>
          </name>
          <aff xml:lang="en">Head of the Hematology Departament at the General Hospital for Diseases of the Guatemalan Social Security Institute of Guatemala (IGSS)</aff>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>01</day>
        <month>07</month>
        <year>2025</year>
      </pub-date>
      <elocation-id>ODMJ-002-0701-4309</elocation-id>
      <permissions>
        <copyright-statement>Copyright (c) 2025 OncoDaily Medical Journal</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>OncoDaily Medical Journal</copyright-holder>
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      <self-uri xlink:href="https://oncodailyjournal.com/10.69690/odmj-002-0701-4309/"/>
      <kwd-group xml:lang="en">
        <kwd>Gastrointestinal cancer</kwd>
        <kwd>Gastrointestinal oncology</kwd>
        <kwd>Guatemala</kwd>
        <kwd>LATAM</kwd>
        <kwd>Latin America</kwd>
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    <ref-list>
      <ref id="R1">
        <mixed-citation>Matta de García VL, De León JL. Characterization of gastric cancer in Guatemala. Rev. cient. 2015. Dec;25(2):9-20</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Instituto Nacional de Estadística. Resultados de la búsqueda de «CANCER GASTRICO». Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209–49.</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Karimi P, Islami F, Anandasabapathy S, et al. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014 May;23(5):700–13.</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Instituto Guatemalteco de Seguridad Social (IGSS). Informe Anual de Labores 2023. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>SEER Cancer Statistics. Cáncer de estómago: datos estadísticos sobre el cáncer. \[Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Matta de García VL, De León JL. Characterization of gastric cancer in Guatemala. Cienc Tecnol Salud. 2015;25(2):00–00.</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Mamun TI, Younus S, Rahman MH. Gastric cancer: epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: an updated review. Cancer Treat Res Commun. 2024;41:100845.</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Instituto Guatemalteco de Seguridad Social (IGSS). El Hospital Modular Zona 11 pone a disposición de los pacientes dos nuevos quirófanos – Noticias IGSS. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Instituto Guatemalteco de Seguridad Social (IGSS). El IGSS es todo un referente en la atención oncológica – Noticias IGSS. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Instituto Guatemalteco de Seguridad Social (IGSS). Boletín Estadístico de Prestaciones en Salud. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Instituto Guatemalteco de Seguridad Social (IGSS). La detección temprana del cáncer de mama es fundamental para la ganar la batalla a esta enfermedad – Noticias IGSS. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Kihn-Alarcón AJ, Toledo-Ponce MF, Velarde A, et al. Liver cancer in Guatemala: an analysis of mortality and incidence trends from 2012 to 2016. J Glob Oncol. 2019 Feb;5:1–8.</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Alvarez CS, Hernández E, Escobar K, et al. Aflatoxin B1 exposure and liver cirrhosis in Guatemala: a case-control study. BMJ Open Gastroenterol. 2020 Jul;7(1):e000380.</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Kihn-Alarcón AJ, Toledo-Ponce MF, Velarde A, et al. Liver cancer in Guatemala: an analysis of mortality and incidence trends from 2012 to 2016. J Glob Oncol. 2019 Feb;5:1–8.</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Aflatoxins and other risk factors for liver cancer, in Guatemala. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Pages J, Mendizabal M, Castro-Narro G, et al. Hepatocellular carcinoma surveillance: current challenges in Latin America. Ann Hepatol. 2025 Jun 20;30(2):101935.</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Ferlay J. Statistics at a glance, 2022 Top 5 most frequent cancers: Number of new cases 17,801. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer; [cited 2025 Jun 23].</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Tso J, Al-Qaraghli M, Galeas S, et al. Gastric cancer in Central America: a scoping review. Ecancermedicalscience. 2025 Jan 23;19:1834.</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Fernandez-Botran R, Wellmann IA, Une C, et al. Seroprevalence of Helicobacter pylori/CagA antibodies in Guatemalan gastric cancer patients: association of seropositivity with increased plasma levels of pepsinogens but not soluble urokinase plasminogen activator receptor. Am J Trop Med Hyg. 2020 Jul;103(1):260–5.</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Ng R, Sutradhar R, Yao Z, Wodchis WP, Rosella LC. Smoking, drinking, diet and physical activity: modifiable lifestyle risk factors and their associations with age to first chronic disease. Int J Epidemiol. 2020 Feb 1;49(1):113–30.</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>American Cancer Society. Stomach cancer treatment choices by stage. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Xu X, Hu Y, Lv N. Eradication of Helicobacter pylori reduces gastric cancer risk by preventing gastric mucosal atrophy and intestinal metaplasia. Cancer Screen Prev. 2024 Dec 25;3(4):227–9.</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Sawicki T, Ruszkowska M, Danielewicz A, et al. A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms, and diagnosis. Cancers (Basel). 2021;13(9):2025.</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Flores Münchmeyer MW, Calel Anaya ME, Ajché J. Caracterización epidemiológica del cáncer colorrectal en el Instituto Guatemalteco de Seguridad Social (IGSS). REV GUATEM CIR. 2020. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Colorectal cancer screening in the Americas: Situation and challenges. [Internet]. [cited 2025 Jun 23].</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Kim H, Melio A, Simianu V, et al. Challenges and opportunities for colorectal cancer prevention in young patients. Cancers (Basel). 2025 Jun 19;17(12):2043.</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Pancreas cancer in Guatemala. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J Oncol. 2019 Feb;10(1):10–27.</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Capasso M, Franceschi M, Rodriguez-Castro KI, et al. Epidemiology and risk factors of pancreatic cancer. Acta Biomed. 2018 Dec 17;89(9-S):141–6.</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Kikuyama M. A novel diagnostic imaging method for the early detection of pancreatic cancer. Diagnostics (Basel). 2023 Jun 15;13(12):2080.</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Winship Cancer Institute of Emory University. Pancreatic cancer prevention. [Internet]. Accessed: Jun. 23, 2025.</mixed-citation>
      </ref>
      <ref id="R33">
        <mixed-citation>Wang Y, Mukkamalla SKR, Singh R, Lyons S. Esophageal cancer. Essence of Anesthesia Practice E-Book. 2024;65.</mixed-citation>
      </ref>
      <ref id="R34">
        <mixed-citation>Rock CL, Thomson C, Gansler T, et al. American Cancer Society guideline for diet and physical activity for cancer prevention. CA Cancer J Clin. 2020 Jul;70(4):245–71.</mixed-citation>
      </ref>
      <ref id="R35">
        <mixed-citation>PDQ Screening and Prevention Editorial Board. PDQ esophageal cancer screening. Bethesda (MD): National Cancer Institute; [cited 11/13/2025}. Available from: https://www.cancer.gov/types/esophageal/hp/esophageal-screening-pdq.</mixed-citation>
      </ref>
      <ref id="R36">
        <mixed-citation>Yang J, Liu X, Cao S, et al. Understanding esophageal cancer: the challenges and opportunities for the next decade. Front Oncol. 2020 Sep 10;10:1727.</mixed-citation>
      </ref>
    </ref-list>
  </back>
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