<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN" "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article article-type="article-commentary" dtd-version="1.4" xmlns:xlink="http://www.w3.org/1999/xlink" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">odmj</journal-id>
      <journal-title-group>
        <journal-title xml:lang="en">OncoDaily Medical Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">ODMJ</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">3067-6444</issn>
      <publisher>
        <publisher-name>OncoDaily Medical Journal</publisher-name>
        <publisher-loc>
          <country>US</country>
        </publisher-loc>
      </publisher>
      <self-uri xlink:href="https://oncodailyjournal.com/"/>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">4320</article-id>
      <article-id pub-id-type="doi">10.69690/ODMJ-018-0425-4320</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Commentaries</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Colorectal Cancer in Latin America: Quick Comment</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>Michaus</surname>
            <given-names>Veronica Salais</given-names>
          </name>
          <aff xml:lang="en">Gastrointestinal Oncology Department and Traslational Medicine Laboratory, Instituto Nacional de Cancerologia, Mexico</aff>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Ruiz-Garcia</surname>
            <given-names>Erika</given-names>
          </name>
          <aff xml:lang="en">Gastrointestinal Oncology Department and Traslational Medicine Laboratory, Instituto Nacional de Cancerologia, Mexico</aff>
          <email>betzabe100@yahoo.com.mx</email>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>21</day>
        <month>07</month>
        <year>2025</year>
      </pub-date>
      <elocation-id>ODMJ-018-0425-4320</elocation-id>
      <permissions>
        <copyright-statement>Copyright (c) 2025 OncoDaily Medical Journal</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>OncoDaily Medical Journal</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://oncodailyjournal.com/10.69690/odmj-018-0425-4320/"/>
      <kwd-group xml:lang="en">
        <kwd>colorectal cancer</kwd>
        <kwd>Commentaries</kwd>
        <kwd>LATAM</kwd>
        <kwd>Latin America</kwd>
      </kwd-group>
      <custom-meta-group>
        <custom-meta>
          <meta-name>production-ready-file-url</meta-name>
          <meta-value>
            <ext-link ext-link-type="uri" xlink:href="https://oncodailyjournal.com/pub/uploads/2025/07/Article-6.pdf"/>
          </meta-value>
        </custom-meta>
      </custom-meta-group>
    </article-meta>
  </front>
  <body/>
  <back>
    <ref-list>
      <ref id="R1">
        <mixed-citation>Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-63.</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Gobierno de México. 131. Necesario modificar estilos de vida para evitar desarrollo de cáncer colorrectal: INCan [Internet]. Secretaría de Salud; [cited 2025 Jul 9]. Available from: https://www.gob.mx/salud/prensa/131-necesario-modificar-estilos-de-vida-para-evitar-desarrollo-de-cancer-colorrectal-incan?idiom=es</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Piñeros M, Laversanne M, Barrios E, et al. An updated profile of the cancer burden, patterns, and trends in Latin America and the Caribbean. Lancet Reg Health Am. 2022 Sep;13:100294.</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Araghi M, Soerjomataram I, Jenkins M, et al. Global trends in colorectal cancer mortality: projections to the year 2035. Int J Cancer. 2019 Jun 15;144(12):2992-3000.</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Muzi CD, Banegas MP, Guimarães RM, et al. Colorectal cancer disparities in Latin America: mortality trends 1990–2019 and a paradox association with human development. PLoS One. 2023 Aug 25;18(8):e0289675.</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>SEER Cancer Statistics. Colorectal cancer [Internet]. National Cancer Institute; [cited 2025 Jul 9]. Available from: https://seer.cancer.gov/statfacts/html/colorect.html</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Reynoso-Noverón N, Meneses-García A, Erazo-Valle A, et al. Challenges in the development and implementation of the National Comprehensive Cancer Control Program in Mexico. Salud Publica Mex. 2016 Apr;58(2):325-33.</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Modest DP, Pant S, Sartore-Bianchi A, et al. Treatment sequencing in metastatic colorectal cancer. Eur J Cancer. 2019 Mar;109:70-83.</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Ji J, Wang C, Fakih M, et al. Targeting KRASG12C-mutated advanced colorectal cancer: research and clinical developments. Onco Targets Ther. 2022 Jul 7;15:747-56.</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Tabernero J, Ros J, Élez E, et al. The evolving treatment landscape in BRAF-V600E-mutated metastatic colorectal cancer. Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-10.</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Seo AN, Kwak Y, Kim DW, et al. HER2 status in colorectal cancer: its clinical significance and the relationship between HER2 gene amplification and expression. PLoS One. 2014 May 30;9(5):e98528.</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>Koopman M, Kortman GA, Mekenkamp L, et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 2009 Jan 27;100(2):266-73.</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Di Mauro A, Santorsola M, Savarese G, et al. High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients. J Transl Med. 2024 Dec 5;22(1):1107.</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>López RI, Castro JL, Cedeño H, et al. Consensus on management of metastatic colorectal cancer in Central America and the Caribbean: San José, Costa Rica, August 2016. ESMO Open. 2018 Mar 15;3(3):e000315.</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Quesada-Soto P, Landaverde D, Ramos-Esquivel A, et al. Liver metastasectomy and systemic therapy improve overall survival compared with surgery alone after curative liver resection of colorectal metastases in a developing country (Costa Rica). J Glob Oncol. 2016 May 4;3(1):31-6.</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Nunes Filho PRS, et al. Latin America and cancer clinical trials: underrepresented region with significant growth potential. J Clin Oncol. 2024;42:e23038.</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Jácome AA, Mathias-Machado MC, Gil M, et al. Later lines of systemic therapy in patients with metastatic colorectal cancer: real-world data from a setting with barriers to access cancer therapies. J Gastrointest Oncol. 2024 Dec 31;15(6):2543-51.</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Catani G, Kim S, Waisberg F, et al. Patients with colorectal cancer and BRAF V600E mutation in Argentina: a real-world study – the EMOGI-CRC01 study. Cancers (Basel). 2025;17(6):1007.</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>O’Connor J, Torrecillas L, Alvarado F, et al. Biomarkers and treatment characteristics in metastatic colorectal cancer RASwt patients in Latin America. Gac Mex Oncol. 2023;22(1):24-33.</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>White C, Scott RJ, Paul C, et al. Ethnic diversity of DPD activity and the DPYD gene: review of the literature. Pharmgenomics Pers Med. 2021 Dec 9;14:1603-17.</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Montalvan-Sanchez EE, Norwood DA, Dougherty M, et al. Colorectal cancer screening programs in Latin America: a systematic review and meta-analysis. JAMA Netw Open. 2024 Feb 5;7(2):e2354256.</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Unger-Saldaña K, Saldaña-Tellez M, Potter MB, et al. Barriers and facilitators for colorectal cancer screening in a low-income urban community in Mexico City. Implement Sci Commun. 2020 Jul 10;1:64.</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: cancer today [Internet]. Lyon, France: International Agency for Research on Cancer; 2024; [cited 2025 Jul 9]. Available from: https://gco.iarc.who.int/today</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Reich M, Buki LP, et al. Colorectal cancer screening in Uruguay: current assessment and roadmap for the future. Psicol Reflex Crit. 2021 Jun 29;34(1):20.</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Colón-López V, Valencia-Torres IM, Ríos EI, et al. Knowledge, attitudes, and beliefs about colorectal cancer screening in Puerto Rico. J Cancer Educ. 2023 Apr;38(2):552-61.</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Fleitas-Kanonnikoff T, Martinez-Ciarpaglini C, Ayala J, et al. Molecular profile in Paraguayan colorectal cancer patients, towards a precision medicine strategy. Cancer Med. 2019 Jun;8(6):3120-30.</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Lima Pérez M, Galán Álvarez YH, Soriano García JL, et al. Incidence and mortality of gastrointestinal cancer in Cuba, 2015–2017. Rev Cubana Oncol. 2021 May-Aug;19(2):e142.</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Mondschein S, Subiabre F, Yankovic N, et al. Colorectal cancer trends in Chile: a Latin-American country with marked socioeconomic inequities. PLoS One. 2022 Nov 10;17(11):e0271929.</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Campo-Sánchez SM, Camargo-Trillos J, Calle-Ramírez JA, et al. Colorectal cancer survival at an oncologic center in Colombia: a historic cohort study. Rev Gastroenterol Mex (Engl Ed). 2019 Apr-Jun;84(2):174-84.</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Campo-Sánchez SM, Camargo-Trillos J, Calle-Ramírez JA, et al. Colorectal cancer survival at an oncologic center in Colombia: a historic cohort study. Rev Gastroenterol Mex (Engl Ed). 2019 Apr-Jun;84(2):174-84.</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Dantas AAG, de Oliveira NPD, Costa GAB, et al. Multilevel analysis of social determinants of advanced stage colorectal cancer diagnosis. Sci Rep. 2024 Apr 26;14(1):9667.</mixed-citation>
      </ref>
      <ref id="R32">
        <mixed-citation>Ramos-Esquivel A, Garita-Rojas E, Masís-Marroquín A, et al. Determinantes de supervivencia en una cohorte de pacientes costarricenses con cáncer colorrectal. Acta Méd Costarric. 2022;64(2):16-23.</mixed-citation>
      </ref>
      <ref id="R33">
        <mixed-citation>Caramutti-Pasco BA, Oyola-García AE, Quispe-Ilanzo MP, et al. Caracterización clínica y colonoscópica del adenocarcinoma colorrectal en un hospital peruano de la seguridad social. Rev Cuerpo Med HNAAA. 2017;10(4).</mixed-citation>
      </ref>
      <ref id="R34">
        <mixed-citation>Cueva P, Tarupi W, Caballero H, et al. Cancer incidence and mortality in Quito: information to monitor cancer control policies. Colomb Med (Cali). 2022 Feb 9;53(1):e2024929.</mixed-citation>
      </ref>
      <ref id="R35">
        <mixed-citation>Lozano-Esparza S, Sánchez-Blas HR, Huitzil-Meléndez FD, et al. Colorectal cancer survival in Mexico: leveraging a national health insurance database. Cancer Epidemiol. 2025 Feb;94:102698.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
