odmj
OncoDaily Medical Journal
ODMJ
3067-6444
OncoDaily Medical Journal
US
5970
10.69690/ODMJ-001-1222-5970
Original Research
Osteomyelitis in Children with Sickle Cell Disease: Is MRI pathognomonic?
Lawati
Murtadha Mohammed Shihab Al
Medical City of Military and security Services, Sultanate of Oman
mmshl1992@gmail.com
Hinai
Zaid Al
Child Health Department, Sultan Qaboos University Hospital
Raniga
Sameer
Radiology Department, Sultan Qaboos University Hospital
Kharus
Ahmed Al
Ministry of Health of Oman
Shukaili
Ahmed Al
Ministry of Health of Oman
Manwari
Shuwaikha Al
Oman Medical Specialty Board
Wali
Yaser
Child Health Department, Sultan Qaboos University Hospital
22
12
2025
ODMJ-001-1222-5970
Copyright (c) 2025 OncoDaily Medical Journal
2025
OncoDaily Medical Journal
children
Magnetic resonance imaging
Osteomyelitis
Pediatrics
Sickle cell disease
production-ready-file-url
[
Al-Kindi RM, Kannekanti S, Natarajan J, et al. Awareness and attitude towards the premarital screening programme among high school students in Muscat, Oman. Sultan Qaboos Univ Med J. 2019;19(3):e217-e224.
]
[
Juwah AI. Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria. Arch Dis Child. 2004;89(6):572-576.
]
[
Yale SH, Nagib N, Guthrie T. Approach to the vaso-occlusive crisis in adults with sickle cell disease. Am Fam Physician. 2000;61(5):1349-1356, 1363-1364.
]
[
Berger E, Saunders N, Wang L, Friedman JN. Sickle cell disease in children: differentiating osteomyelitis from vaso-occlusive crisis. Arch Pediatr Adolesc Med. 2009;163(3):251-255.
]
[
Al Farii H, Zhou S, Albers A. Management of osteomyelitis in sickle cell disease: review article. J Am Acad Orthop Surg Glob Res Rev. 2020;4(9):e20.00002-10
]
[
da Silva Junior GB, Daher EDF, da Rocha FAC. Osteoarticular involvement in sickle cell disease. Rev Bras Hematol Hemoter. 2012;34(2):156-164.
]
[
Fritz JM, McDonald JR. Osteomyelitis: approach to diagnosis and treatment. Phys Sportsmed. 2008;36(1):nihpa116823.
]
[
Al Shukaili AK, Al Kharusi AA, Tbaileh E, et al. Clinical and magnetic resonance imaging decision making rules in differentiating vaso-occlusive crises from osteomyelitis in paediatric sickle cell population: is MRI pathognomonic? Blood. 2019;134(Suppl 1):4824.
]
[
Kao CM, Yee ME, Maillis A, et al. Microbiology and radiographic features of osteomyelitis in children and adolescents with sickle cell disease. Pediatr Blood Cancer. 2020;67(10):e28517.
]
[
White LM, Schweitzer ME, Deely DM, Gannon F. Study of osteomyelitis: utility of combined histologic and microbiologic evaluation of percutaneous biopsy samples. Radiology. 1995;197(3):840-842.
]
[
Le Saux N. Diagnosis and management of acute osteoarticular infections in children. Paediatr Child Health. 2018;23(5):336-343.
]
[
Amundsen TR, Siegel MJ, Siegel BA. Osteomyelitis and infarction in sickle cell hemoglobinopathies: differentiation by combined technetium and gallium scintigraphy. Radiology. 1984;153(3):807-812.
]
[
Kahn CE, Ryan JW, Hatfield MK, Martin WB. Combined bone marrow and gallium imaging: differentiation of osteomyelitis and infarction in sickle hemoglobinopathy. Clin Nucl Med. 1988;13(6):443-449.
]
[
Booz MMY, Hariharan V, Aradi AJ, Malki AA. The value of ultrasound and aspiration in differentiating vaso-occlusive crisis and osteomyelitis in sickle cell disease patients. Clin Radiol. 1999;54(10):636-639.
]
[
William RR, Hussein SS, Jeans WD, Wali YA, Lamki ZA. A prospective study of soft-tissue ultrasonography in sickle cell disease patients with suspected osteomyelitis. Clin Radiol. 2000;55(4):307-310.
]
[
Inusa BPD, Oyewo A, Brokke F, Santhikumaran G, Jogeesvaran KH. Dilemma in differentiating between acute osteomyelitis and bone infarction in children with sickle cell disease: the role of ultrasound. PLoS One. 2013;8(6):e65001.
]
[
Scruggs M, Pateva I. Multifocal osteomyelitis in a child with sickle cell disease and review of the literature regarding best diagnostic approach. Clin Case Rep. 2023;11(7):e7288.
]
[
Delgado J, Bedoya MA, Green AM, Jaramillo D, Ho-Fung V. Utility of unenhanced fat-suppressed T1-weighted MRI in children with sickle cell disease: can it differentiate bone infarcts from acute osteomyelitis? Pediatr Radiol. 2015;45(13):1981-1987.
]
[
Schooler GR, Davis JT, Daldrup-Link HE, Frush DP. Current utilization and procedural practices in pediatric whole-body MRI. Pediatr Radiol. 2018;48(8):1101-1107.
]
[
Kumar R, Basu S, Torigian D, et al. Role of modern imaging techniques for diagnosis of infection in the era of 18F-fluorodeoxyglucose positron emission tomography. Clin Microbiol Rev. 2008;21(1):209-224.
]
[
Nehring SM, Goyal A, Patel BC. C-reactive protein. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. Accessed Dec 24, 2023.
]
[
De S, Williams GJ, Hayen A, et al. Value of white cell count in predicting serious bacterial infection in febrile children under 5 years of age. Arch Dis Child. 2014;99(6):493-499.
]
[
Kim-Shapiro DB, Gladwin MT. Nitric oxide pathology and therapeutics in sickle cell disease. Clin Hemorheol Microcirc. 2018;68(2-3):223-237.
]