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      <journal-id journal-id-type="publisher-id">odmj</journal-id>
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        <journal-title xml:lang="en">OncoDaily Medical Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">ODMJ</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">3067-6444</issn>
      <publisher>
        <publisher-name>OncoDaily Medical Journal</publisher-name>
        <publisher-loc>
          <country>US</country>
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    <article-meta>
      <article-id pub-id-type="publisher-id">6102</article-id>
      <article-id pub-id-type="doi">10.69690/ODMJ-001-1210-6102</article-id>
      <article-categories>
        <subj-group xml:lang="en" subj-group-type="heading">
          <subject>Original Research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Survival and Challenges with Multimodal Treatment in Children with Rhabdomyosarcoma - Real Scenario from A Resource-limited Center of Bangladesh</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Begum</surname>
            <given-names>Ferdousi</given-names>
          </name>
          <aff xml:lang="en">Pediatric Hematology and Oncology Department, National Institute of Cancer Research and Hospital, Bangladesh</aff>
          <email>aferdousi02@mail.com</email>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2144-4837</contrib-id>
          <name name-style="western">
            <surname>Yasmin</surname>
            <given-names>Farida</given-names>
          </name>
          <aff xml:lang="en">Pediatric Hematology and Oncology Department, National Institute of Cancer Research and Hospital, Bangladesh</aff>
        </contrib>
        <contrib contrib-type="author">
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-1131-3436</contrib-id>
          <name name-style="western">
            <surname>Rahman</surname>
            <given-names>Rezwana</given-names>
          </name>
          <aff xml:lang="en">Pediatric Hematology and Oncology Department, National Institute of Cancer Research and Hospital, Bangladesh</aff>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>10</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <elocation-id>ODMJ-001-1210-6102</elocation-id>
      <permissions>
        <copyright-statement>Copyright (c) 2025 OncoDaily Medical Journal</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>OncoDaily Medical Journal</copyright-holder>
      </permissions>
      <self-uri xlink:href="https://oncodailyjournal.com/10.69690/odmj-001-1210-6102/"/>
      <kwd-group xml:lang="en">
        <kwd>Bangladesh</kwd>
        <kwd>childhood rhabdomyosarcoma</kwd>
        <kwd>Rhabdomyosarcoma</kwd>
      </kwd-group>
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    <ref-list>
      <ref id="R1">
        <mixed-citation>Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995 Apr 15;75(8):2186-95.</mixed-citation>
      </ref>
      <ref id="R2">
        <mixed-citation>Ries LAG, Kosary CL, Hankey BF, Miller BA, Clegg L, Edwards BK (eds). SEER Cancer Statistics Review, 1973-1996, National Cancer Institute. Bethesda, MD, 1999.</mixed-citation>
      </ref>
      <ref id="R3">
        <mixed-citation>Donaldson SS, Meza J, Breneman JC, Crist WM, Laurie F, Qualman SJ, Wharam M; Children’s Oncology Group Soft Tissue Sarcoma Committee (formely Intergroup Rhabdomyosarcoma Group) representing the Children’s Oncology Group and the Quality Assurance Review Center. Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma–a report from the IRSG. Int J Radiat Oncol Biol Phys. 2001 Nov 1;51(3):718-28.</mixed-citation>
      </ref>
      <ref id="R4">
        <mixed-citation>Stevens MC, Rey A, Bouvet N, et al. Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology–SIOP Malignant Mesenchymal Tumor 89. J Clin Oncol. 2005 Apr 20;23(12):2618-28.</mixed-citation>
      </ref>
      <ref id="R5">
        <mixed-citation>Donaldson SS, Anderson JR. Rhabdomyosarcoma: many similarities, a few philosophical differences. J Clin Oncol. 2005 Apr 20;23(12):2586-7.</mixed-citation>
      </ref>
      <ref id="R6">
        <mixed-citation>Raney RB, Anderson JR, Barr FG, et al. Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V. J Pediatr Hematol Oncol. 2001 May;23(4):215-20.</mixed-citation>
      </ref>
      <ref id="R7">
        <mixed-citation>Crist W, Gehan EA, Ragab AH, et al. The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 1995 Mar;13(3):610-30.</mixed-citation>
      </ref>
      <ref id="R8">
        <mixed-citation>Cecchetto G, Bisogno G, De Corti F, et al. Italian Cooperative Group. Biopsy or debulking surgery as initial surgery for locally advanced rhabdomyosarcomas in children?: the experience of the Italian Cooperative Group studies. Cancer. 2007 Dec 1;110(11):2561-7.</mixed-citation>
      </ref>
      <ref id="R9">
        <mixed-citation>Crist WM, Anderson JR, Meza JL, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001 Jun 15;19(12):3091-102.</mixed-citation>
      </ref>
      <ref id="R10">
        <mixed-citation>Gupta AA, Anderson JR, Pappo AS, et al. Patterns of chemotherapy-induced toxicities in younger children and adolescents with rhabdomyosarcoma: a report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Cancer. 2012 Feb 15;118(4):1130-7.</mixed-citation>
      </ref>
      <ref id="R11">
        <mixed-citation>Breneman JC, Lyden E, Pappo AS, et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma–a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol. 2003 Jan 1;21(1):78-84.</mixed-citation>
      </ref>
      <ref id="R12">
        <mixed-citation>HaDuong JH, Martin AA, Skapek SX, Mascarenhas L. Sarcomas. Pediatr Clin North Am. 2015 Feb;62(1):179-200.</mixed-citation>
      </ref>
      <ref id="R13">
        <mixed-citation>Lawrence W Jr, Gehan EA, Hays DM, Beltangady M, Maurer HM. Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS-II). J Clin Oncol. 1987 Jan;5(1):46-54.</mixed-citation>
      </ref>
      <ref id="R14">
        <mixed-citation>Lawrence W Jr, Anderson JR, Gehan EA, Maurer H. Pretreatment TNM staging of childhood rhabdomyosarcoma: a report of the Intergroup Rhabdomyosarcoma Study Group. Children’s Cancer Study Group. Pediatric Oncology Group. Cancer. 1997 Sep 15;80(6):1165-70.</mixed-citation>
      </ref>
      <ref id="R15">
        <mixed-citation>Crist WM, Garnsey L, Beltangady MS, et al. Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. Intergroup Rhabdomyosarcoma Committee. J Clin Oncol. 1990 Mar;8(3):443-52.</mixed-citation>
      </ref>
      <ref id="R16">
        <mixed-citation>Gartrell J, Pappo A. Recent advances in understanding and managing pediatric rhabdomyosarcoma. F1000Res. 2020 Jul 8;9:F1000 Faculty Rev-685.</mixed-citation>
      </ref>
      <ref id="R17">
        <mixed-citation>Walterhouse DO, Pappo AS, et al. Shorter-duration therapy using vincristine, dactinomycin, and lower-dose cyclophosphamide with or without radiotherapy for patients with newly diagnosed low-risk rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. J Clin Oncol. 2014 Nov 1;32(31):3547-52.</mixed-citation>
      </ref>
      <ref id="R18">
        <mixed-citation>Walterhouse DO, Pappo AS, Meza JL, et al. Reduction of cyclophosphamide dose for patients with subset 2 low-risk rhabdomyosarcoma is associated with an increased risk of recurrence: A report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Cancer. 2017 Jun 15;123(12):2368-2375.</mixed-citation>
      </ref>
      <ref id="R19">
        <mixed-citation>Arndt CA, Stoner JA, Hawkins DS, et al. Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children’s oncology group study D9803. J Clin Oncol. 2009 Nov 1;27(31):5182-8.</mixed-citation>
      </ref>
      <ref id="R20">
        <mixed-citation>Hawkins DS, Chi YY, Anderson JR, et al. Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children’s Oncology Group. J Clin Oncol. 2018 Sep 20;36(27):2770-2777.</mixed-citation>
      </ref>
      <ref id="R21">
        <mixed-citation>Casey DL, Chi YY, Donaldson SS, et al. Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children’s Oncology Group. Cancer. 2019 Sep 15;125(18):3242-3248.</mixed-citation>
      </ref>
      <ref id="R22">
        <mixed-citation>Bisogno G, De Salvo GL, Bergeron C, et al. European paediatric Soft tissue sarcoma Study Group. Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2019 Nov;20(11):1566-1575.</mixed-citation>
      </ref>
      <ref id="R23">
        <mixed-citation>Weigel BJ, Lyden E, Anderson JR, et al. Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients With High-Risk Rhabdomyosarcoma: A Report From the Children’s Oncology Group. J Clin Oncol. 2016 Jan 10;34(2):117-22.</mixed-citation>
      </ref>
      <ref id="R24">
        <mixed-citation>Schoot RA, Chisholm JC, Casanova M, et al. Metastatic Rhabdomyosarcoma: Results of the European Paediatric Soft Tissue Sarcoma Study Group MTS 2008 Study and Pooled Analysis With the Concurrent BERNIE Study. J Clin Oncol. 2022 Nov 10;40(32):3730-3740.</mixed-citation>
      </ref>
      <ref id="R25">
        <mixed-citation>Hadley LG, Rouma BS, Saad-Eldin Y. Challenge of pediatric oncology in Africa. Semin Pediatr Surg. 2012 May;21(2):136-41.</mixed-citation>
      </ref>
      <ref id="R26">
        <mixed-citation>Rahman ATM,Begum M, CSH Kibria et al.: Outcome of paediatric rhabdomyosarcoma attended in a tertiary care hospital, Dhaka, Bangladesh. Bangladesh Medical Research Council Bulletin. 2020 Jun 10; 46(1):17-21</mixed-citation>
      </ref>
      <ref id="R27">
        <mixed-citation>Leaphart C, Rodeberg D. Pediatric surgical oncology: management of rhabdomyosarcoma. Surg Oncol. 2007 Nov;16(3):173-85.</mixed-citation>
      </ref>
      <ref id="R28">
        <mixed-citation>Lawrence W Jr, Hays DM, Heyn R, Beltangady M, Maurer HM. Surgical lessons from the Intergroup Rhabdomyosarcoma Study (IRS) pertaining to extremity tumors. World J Surg. 1988 Oct;12(5):676-84.</mixed-citation>
      </ref>
      <ref id="R29">
        <mixed-citation>Lawrence W Jr, Neifeld JP. Soft tissue sarcomas. Curr Probl Surg. 1989 Nov;26(11):753-827.</mixed-citation>
      </ref>
      <ref id="R30">
        <mixed-citation>Hays DM, Lawrence W Jr, Wharam M, et al. Primary reexcision for patients with ‘microscopic residual’ tumor following initial excision of sarcomas of trunk and extremity sites. J Pediatr Surg. 1989 Jan;24(1):5-10.</mixed-citation>
      </ref>
      <ref id="R31">
        <mixed-citation>Rodeberg DA, Wharam MD, Lyden ER, et al. Delayed primary excision with subsequent modification of radiotherapy dose for intermediate-risk rhabdomyosarcoma: a report from the Children’s Oncology Group Soft Tissue Sarcoma Committee. Int J Cancer. 2015 Jul 1;137(1):204-11.</mixed-citation>
      </ref>
    </ref-list>
  </back>
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