odmj OncoDaily Medical Journal ODMJ 3067-6444 OncoDaily Medical Journal US 6131 10.69690/ODMJ-001-0310-6131 Original Research Prevalence and Associated Factors of Cholelithiasis in Pediatric Sickle Cell Disease Patients at Qatif Health Network, Saudi Arabia Julaih Hana Al Hematology Unit, Department of Pediatrics, Qatif Health Network, Qatif, Eastern Province, Saudi Arabia hhaljulaih@moh.gov.sa Darwish Mohammed Al Hematology Unit, Department of Pediatrics, Qatif Health Network, Qatif, Eastern Province, Saudi Arabia Khalifah Ahmed Al Hematology Unit, Department of Pediatrics, Qatif Health Network, Qatif, Eastern Province, Saudi Arabia Sadeq Kauther Al Hematology Unit, Department of Pediatrics, Qatif Health Network, Qatif, Eastern Province, Saudi Arabia Alrashed Manar Hematology Unit, Department of Pediatrics, Qatif Health Network, Qatif, Eastern Province, Saudi Arabia 10 03 2026 ODMJ-001-0310-6131 Copyright (c) 2026 OncoDaily Medical Journal 2026 OncoDaily Medical Journal Cholelithiasis Pediatric Oncology Care Pediatric Sickle Cell Disease production-ready-file-url Vichinsky EP. Overview of compound sickle cell syndromes. In: UpToDate, Post TW (Ed). UpToDate [Internet]. Waltham (MA): Wolters Kluwer; 2026. Martins RA, Soares RS, De Vito Fb, et al. Cholelithiasis and its complications in sickle cell disease in a university hospital. Rev Bras Hematol Hemoter.2017; 39(1): 28–31. Alhawsawi ZM, Alshenqeti AM, Algarafi AM, Turkistani W. Cholelithiasis in patients with paediatric sickle cell anaemia in a Saudi hospital. J Taibah Univ Med Sci. 2019;14(2):187–192. Almudaibigh AH, Alkasim FA, Ghareeb EF. Prevalence and outcome of cholelithiasis in children with sickle cell disease at King Saud Medical City, Saudi Arabia. J App Hem. 2021;12(4): 203-209. Attalla BI. Abdominal sonographic findings in Sudanese children with sickle cell anaemia. J Diagn Med Sonography. 2010;26:276-80. Kamdem A, Arnaud C, Me×dejel N, Tassel C, Hau I, Pissard S, et al. Gallstones in a newborn-cohort with sickle cell anemia (SCA): Cumulative risk and predictive factors. Blood. 2011;118:513. Webb DK, Darby JS, Dunn DT, Terry SI, Serjeant GR. Gall stones in Jamaican children with homozygous sickle cell disease. Arch Dis Child. 1989;64:693-696. Ezer A, Torer N, Nursal TZ, et al. Incidence of congenital hemolytic anemias in young cholelithiasis patients. World J Gastroenterol. 2010; 16(43): 5457–5461. Huang YY, Huang CS, Yang SS, et al. Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. World J Gastroenterol. 2005;11(36):5710-3. Meloni T, Forteleoni G, Noja G, et al. Increased prevalence of Glucose-6-phosphate dehydrogenase deficiency in patients with cholelithiasis. Acta Haematol. 1991;85(2):76-8. Cuzzolin L, Oggiano AM, Clemente GM, et al. Ceftriaxone-associated biliary pseudolithiasis in children: do we know enough? Fundam Clin Pharmacol. 2021;35(1):40-52. von Martels JZ, Van de Meeberg EK, Holman M, Ligtenberg JJ, Ter Maaten JC. Pseudolithiasis after recent use of ceftriaxone: an unexpected diagnosis in a child with abdominal pain. Am J Emerg Med. 2013;31:1294. Serdaroglu F, Koca YS, Saltik F, Koca T, Dereci S, Akcam M, Akcam FZ. Gallstones in childhood: etiology, clinical features, and prognosis. Eur J Gastroenterol Hepatol. 2016;28:1468-1472. Bickford CL, Spencer AP. Biliary sludge and hyperbilirubinemia associated with ceftriaxone in an adult: case report and review of the literature. Pharmacotherapy. 2005;25:1389-1395.